Research Division: Genetic Immunotherapy

Barden, M., Holzinger, A., Velas, L., Mezősi-Csaplár, M., Szöőr, A., Vereb, G., Schütz, G. J., Hombach, A. A., Abken, H., CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation. Frontiers Immunol., 14: 1110482 (2023) doi: 10.3389/fimmu.2023.1110482

Hombach, A.A., Barden, M., Hannappel, L., Chmielewski, M., Rappl, G., Sachinidis, A., Abken, H., IL12 integrated into the CAR exodomain converts CD8+ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors. Mol. Ther. 30, 593 – 605 (2022). doi: 10.1016/j.ymthe.2021.10.011

Blokon-Kogan, D., Levi-Mann, M., Malka-Levy, L., Itzhaki, O., Besser, M.J., Shiftan, Y., Szöőr, A., Vereb, G., Gross, G., Abken, H., Weinstein-Marom, H., Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell anti-tumor capacities for adoptive cell therapy. J. Immunother. Cancer, 10, e001544 (2022), doi: 10.1136/jitc-2020-001544

Bunse, M., Pfeilschifter, J., Bluhm, J., Zschummel, N., Foedicke, J. J., Wirges, A., Stark, H., Kretschmer, V., Chmielewski, M., Uckert, W., Abken, H., Westermann, J., Rehm, A., Höpken, U. E., CXCR5 CAR-T cells simultaneously target B cell Non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells. Nat. Comm. 12, 240 (2021). doi: 10.1038/s41467-020-20488-3

Abken, H., Building on synthetic immunology and T cell engineering: a brief journey through the history of chimeric antigen recep. Hum. Gene Ther., 32, 1011-1028 (2021). doi.org/10.1089/hum.2021.165