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LDH inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor Immunity

  • Authors

    • Prof. Luca Gattinoni

    • Prof. Luca Gattinoni

  • Date Published

    August 17, 2020

Hermans D, Gautam S, García-Cañaveras JC, Gromer D, Mitra S, Spolski R, Li P, Christensen SM, Nguyen R, Lin JX, Oh J, Du N, Veenbergen S, Fioravanti J, Ebina-Shibuya R, Bleck CKE, Neckers L, Rabinowitz JD, Gattinoni L, Leonard WJ. LDH inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor Immunity. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6047-6055. doi: 10.1073/pnas.1920413117. PMID: 32123114