The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

Göttert S, Thiele Orberg E, Fan K, Heinrich P, Matthe DM, Khalid O, Klostermeier L, Suriano C, Strieder N, Gebhard C, Vonbrunn E, Mamilos A, Hirsch D, Meedt E, Kleigrewe K, Hiergeist A, Schwarz A, Glasner J, Ghimire S, Joachim L, Voll F, Neuhaus K, Janssen KP, Perl M, Pielmeier F et al. The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration. Nat Commun. 2025 Oct 20. 16:9282. doi:10.1038/s41467-025-65180-6. PMID: 41115965