Publications
Research at the Leibniz Institute for Immunology focuses on the development of pioneering immune-cell therapies targeting cancer, autoimmune diseases, and chronic inflammation. While developments in this field are highly relevant within the medical community, they are also of great interest to the wider general public. The LIT has a comprehensive archive of international articles, publications, lectures, and online resources aimed at a variety of audiences. So, whoever you are, if you do not find what you are looking for, please do not hesitate to contact us.
Weber D, Meedt E, Ghimire S, Hiergeist A, Kern MAG, Hopting M, Thiele Orberg E, Shaikh H, Beilhack A, Wolff D, Edinger M, Herr W, Gessner A, Poeck H, Holler E. “The antibiotic paradox” in allogeneic stem cell transplantation. Bone Marrow Transplant. 2025 Nov. 60:1541–1543. doi:10.1038/s41409-025-02706-y. PMID: 40903551
Simeth J, Engelmann S, Mayr R, Kaelble S, Weber F, Pichler R, Dettmer K, Oefner PJ, Horing M, Symeou L, Freitag K, Wagner K, Burger M, Herr W, Kreutz M, Spang R, Liebisch G, Siska PJ. Lipid metabolism of clear cell renal cell carcinoma predicts survival and affects intratumoral CD8 T cells. Transl Oncol. 2025 Nov. 61:102513. doi:10.1016/j.tranon.2025.102513. PMID: 40902455
Göttert S, Orberg ET, Fan K, Heinrich P, Matthe DM, Khalid O, Klostermeier L, Suriano C, Strieder N, Gebhard C, Vonbrunn E, Mamilos A, Hirsch D, Meedt E, Kleigrewe K, Hiergeist A, Gläsner J, Ghimire S, Joachim L, Voll F, Neuhaus K, Janssen K-P, Perl M, Pielmeier F, Ruland J et al. 2025
A microbial metabolite protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration doi:10.1101/2025.04.08.647747.
Trselic T, Pelo N, Martin de Fremont G, Iyer VS, Richardsdotter Andersson E, Ottosson V, Frei DA, Baas E, Nyberg WA, Thorlacius GE, Mentlein L, Boddul SV, Sandu I, Velasquez Pulgarin D, Vegvari A, Gerlach C, Wermeling F, Sunnerhagen M, Wallner B, Espinosa A, Wahren-Herlenius M. Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility. Proc Natl Acad Sci U S A. 2025 Oct 7. 122:e2426917122. doi:10.1073/pnas.2426917122. PMID: 41042840
Si Y, Fan Y, Scheller L, Stefanov BA, Lv J, Wang Z, Xie M, Fussenegger M. Engineering mammalian cells for detection and treatment of cardiac injury. Mol Syst Biol. 2025 Oct 10. doi:10.1038/s44320-025-00161-x. PMID: 41073800
Göttert S, Thiele Orberg E, Fan K, Heinrich P, Matthe DM, Khalid O, Klostermeier L, Suriano C, Strieder N, Gebhard C, Vonbrunn E, Mamilos A, Hirsch D, Meedt E, Kleigrewe K, Hiergeist A, Schwarz A, Glasner J, Ghimire S, Joachim L, Voll F, Neuhaus K, Janssen KP, Perl M, Pielmeier F et al. The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration. Nat Commun. 2025 Oct 20. 16:9282. doi:10.1038/s41467-025-65180-6. PMID: 41115965
Gurer Kluge EE, Meedt E, Feicht J, Cao K, Hiergeist A, Mamilos A, Hirsch D, Hoepting MDm, Kattner ASDm, Matos C, Bulow S, Thiele Orberg E, Beckhove P, Kandulski A, Evert M, Hildner K, Kreutz M, Edinger M, Wolff D, Herr W, Poeck H, Gessner A, Weber DA, Kehr B, Holler EPDm et al. Mucosal calprotectin is associated with severity of aGI-GVHD and poor outcomes after allogeneic stem cell transplantation. Blood. 2025 Oct 1. doi:10.1182/blood.2025029402. PMID: 41032750
Ebrahimi S, Lohnes BJ, Khan SA, Peipp M, Bockamp E, Klein C, Abken H, Wolfel C, Theobald M, Hartwig UF. Targeting mutated KRAS by HLA-A*02:01 restricted anti-KRAS TCR-mimic CAR and bispecific T cell engager. J Mol Med (Berl). 2025 Oct. 103:1231–1246. doi:10.1007/s00109-025-02585-2. PMID: 40794198
Baldwin JG, Heuser-Loy C, Gattinoni L. Targeting organelle function in T cells for cancer immunotherapy. Nat Rev Immunol. 2025 Oct 9. doi:10.1038/s41577-025-01223-9. PMID: 41068297