Delacher M, Schmidleithner L, Simon M, Stüve P, Sanderink L, Hotz-Wagenblatt A, Wuttke M, Schambeck K, Ruhland B, Hofmann V, Bittner S, Ritter U, Pant A, Helbich SS, Voss M, Lemmermann NA, Bessiri-Schake L, Bohn T, Eigenberger A, Menevse AN, Gebhard C, Strieder N, Abken H, Rehli M, Huehn J, Beckhove P, Hehlgans T, Junger H, Geissler EK, Prantl L, Werner JM, Schmidl C, Brors B, Imbusch CD, Feuerer M. The effector program of human CD8 T cells supports tissue remodeling. J Exp Med. 2024; 221(2):e20230488.
Publications
Research at the Leibniz Institute for Immunology focuses on the development of pioneering immune-cell therapies targeting cancer, autoimmune diseases, and chronic inflammation. While developments in this field are highly relevant within the medical community, they are also of great interest to the wider general public. The LIT has a comprehensive archive of international articles, publications, lectures, and online resources aimed at a variety of audiences. So, whoever you are, if you do not find what you are looking for, please do not hesitate to contact us.
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Bittner S, Hehlgans T, Feuerer M. Engineered Treg Cells as Putative Therapeutics Against Inflammatory Diseases and Beyond. Trends in Immunology, 2023; 44(6):468-483.
Barden, M., Holzinger, A., Velas, L., Mezősi-Csaplár, M., Szöőr, A., Vereb, G., Schütz, G. J., Hombach, A. A., Abken, H., CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation. Frontiers Immunol., 14: 1110482 (2023) doi: 10.3389/fimmu.2023.1110482
Hombach, A.A., Barden, M., Hannappel, L., Chmielewski, M., Rappl, G., Sachinidis, A., Abken, H., IL12 integrated into the CAR exodomain converts CD8+ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors. Mol. Ther. 30, 593 – 605 (2022). doi: 10.1016/j.ymthe.2021.10.011
Lüpken R, Krannich T, Kehr B. Bcmap: fast alignment-free barcode mapping for linked-read sequencing data. bioRxiv 2022, doi: https://doi.org/10.1101/2022.06.20.496811.
Bethge WA, Martus P, Schmitt M, Holtick U, Subklewe M, von Tresckow B, Ayuk F, Wagner-Drouet EM, Wulf GG, Marks R, Penack O, Schnetzke U, Koenecke C, von Bonin M, Stelljes M, Glass B, Baldus CD, Vucinic V, Mougiakakos D, Topp MS, Fante MA, Schroers R, Bayir LM, Borchmann P, Buecklein V, Hanoun C, Thomas S, Beelen DW, Lengerke C, Kroeger N, Dreger P. GLA/DRST real-world outcome analysis of CAR-T cell therapies for large B-cell lymphoma in Germany. Blood 2022; 140(4):349
Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells. Riegel D, Romero-Fernández E, Simon M, Adenugba AR, Singer K, Mayr R, Weber F, Imbusch CD, Kreutz M, Brors B, Ugele I, Werner JM, Siska PJ, Schmidl C. bioRxiv:2022.2003.2016.484513 (2022)
Minderjahn J, Fischer A, Maier K, Mendes K, Nuetzel M, Raithel J, Stanewsky H, Ackermann U, Mansson R, Gebhard C, and Rehli M (2022). Postmitotic differentiation of human monocytes requires cohesin-structured chromatin. Nat Commun 13: 4301.
Krannich T, White WTJ, Niehus S, Holley G, Halldórsson BV, Kehr B. Population-scale detection of non-reference sequence variants using colored de Bruijn Graphs. Bioinformatics 2022, 38(3):604-611.
Camara A, Lavanant AC, Abe J, Desforges HL, Alexandre YO, Girardi E, Igamberdieva Z, Asano K, Tanaka M, Hehlgans T, Pfeffer K, Pfeffer S, Mueller SN, Stein JV, Mueller CG. CD169+ macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3). PMID: 35031565