Publications
Research at the Leibniz Institute for Immunology focuses on the development of pioneering immune-cell therapies targeting cancer, autoimmune diseases, and chronic inflammation. While developments in this field are highly relevant within the medical community, they are also of great interest to the wider general public. The LIT has a comprehensive archive of international articles, publications, lectures, and online resources aimed at a variety of audiences. So, whoever you are, if you do not find what you are looking for, please do not hesitate to contact us.
Brummer C, Singer K, Henrich F, Peter K, Strobl C, Neueder B, Bruss C, Renner K, Pukrop T, Herr W, Aigner M, Kreutz M. The Tumor Metabolite 5′-Deoxy-5’Methylthioadenosine (MTA) Inhibits Maturation and T Cell-Stimulating Capacity of Dendritic Cells. Cells. 2024 Dec 20. 13doi:10.3390/cells13242114. PMID: 39768204
Barden M, Elsenbroich PR, Haas V, Ertelt M, Pervan P, Velas L, Gergely B, Szoor A, Harrer DC, Bezler V, Holzinger A, Friis RUW, Vereb G, Schutz GJ, Schoeder CT, Hombach AA, Abken H. Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function. J Immunother Cancer. 2024 Dec 2. 12doi:10.1136/jitc-2024-010208. PMID: 39622582
Simeth J, Huttl P, Schon M, Nozari Z, Huttner M, Schmidt T, Altenbuchinger M, Spang R. Virtual tissue expression analysis. Bioinformatics. 2024 Nov 28. 40doi:10.1093/bioinformatics/btae709. PMID: 39589902
Galletti G, De Simone G, Mazza EMC, Puccio S, Mezzanotte C, Bi TM, Davydov AN, Metsger M, Scamardella E, Alvisi G, De Paoli F, Zanon V, Scarpa A, Camisa B, Colombo FS, Anselmo A, Peano C, Polletti S, Mavilio D, Gattinoni L, Boi SK, Youngblood BA, Jones RE, Baird DM, Gostick E et al. Two subsets of stem-like CD8(+) memory T cell progenitors with distinct fate commitments in humans. Nat Immunol. 2020 Dec. 21:1552-1562. doi:10.1038/s41590-020-0791-5. PMID: 33046887
Denk A, Mittermaier C, Weber D, Fante M, Gunes S, Edinger M, Herr W, Wolff D. Efficacy and safety of ruxolitinib in the treatment of chronic graft-versus-host disease: a retrospective analysis. Ann Hematol. 2024 Sep. 103:3755-3764. doi:10.1007/s00277-024-05697-w. PMID: 38916742
Schelker RC, Fioravanti J, Mastrogiovanni F, Baldwin JG, Rana N, Li P, Chen P, Vadász T, Spolski R, Heuser-Loy C, Slavkovic-Lukic D, Noronha P, Damiano G, Raccosta L, Maggioni D, Pullugula S, Lin JX, Oh J, Grandinetti P, Lecce M, Hesse L, Kocks E, Martín-Santos A, Gebhard C, Telford WG, Ji Y, Restifo NP, Russo V, Rehli M, Herr W, Leonard WJ, Gattinoni L. LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling. Signal Transduct Target Ther. 2024 Aug 9;9(1):199. doi: 10.1038/s41392-024-01915-z. PMID: 39117617
Perl M, Herfeld K, Harrer DC, Hopting M, Schweiger M, Sterz U, Knodler L, Heimerl S, Hansmann L, Herr W, Poeck H, Wolff D, Edinger M, Hart C, Fante MA. Tocilizumab administration in cytokine release syndrome is associated with hypofibrinogenemia after chimeric antigen receptor T-cell therapy for hematologic malignancies. Haematologica. 2024 Sep 1. 109:2969-2977. doi:10.3324/haematol.2023.284564. PMID: 38546698
Schmidleithner L, Stuve P, Feuerer M. FOXP3 snatches transcription factors depending on the context. J Exp Med. 2024 Sep 2. 221doi:10.1084/jem.20240940. PMID: 38949640
Schreiber L, Ghimire S, Hiergeist A, Renner K, Althammer M, Babl N, Peuker A, Schoenhammer G, Hippe K, Gessner A, Albrecht C, Pielmeier F, Buttner-Herold M, Bruns H, Hoffmann P, Herr W, Holler E, Peter K, Kreutz M, Matos C. Strain specific differences in vitamin D3 response: impact on gut homeostasis. Front Immunol. 2024 15:1347835. doi:10.3389/fimmu.2024.1347835. PMID: 38495883
Fischer-Riepe L, Kailayangiri S, Zimmermann K, Pfeifer R, Aigner M, Altvater B, Kretschmann S, Volkl S, Hartley J, Dreger C, Petry K, Bosio A, von Dollen A, Hartmann W, Lode H, Gorlich D, Mackensen A, Jungblut M, Schambach A, Abken H, Rossig C. Preclinical Development of CAR T Cells with Antigen-Inducible IL18 Enforcement to Treat GD2-Positive Solid Cancers. Clin Cancer Res. 2024 Aug 15. 30:3564-3577. doi:10.1158/1078-0432.CCR-23-3157. PMID: 38593230