Home | Research | Research Groups | Structural Biochemistry Structural Biochemistry Research We are a new lab, starting in 2025. Our group develops synthetic receptors and protein therapeutics to improve the safety and efficacy of immunotherapies. We combine: Computational protein design to create specific and tunable biosensors and receptors. Synthetic biology approaches to reprogram cellular functions and immune responses. High-throughput screening and functional validation in relevant models. Our interdisciplinary and collaborative approach aims to bridge basic and translational research to address current bottlenecks in immunotherapy. A major challenge for engineered immune cells is their limited ability to target solid tumors without causing on-target, off-tumor toxicity. To reduce this limitation, we develop synthetic receptors and protein therapeutics that respond to key stimuli from the tumor microenvironment, aiming to improve the specificity and efficacy of immunotherapies. In one approach the tumor targeting domain is secreted by the CAR-T cell. The sensor domains (binder 1 & 2) only associate in the presence of a soluble biomarker. Team & Lab Life Dr. Leo Scheller Head of Research Group | Structural Biochemistry Email: info@lit.eu We are just getting started! Check for open positions and help us build a creative, inclusive, awesome lab to do meaningful work in immunotherapy!
