Review Article published in nature reviews immunology

nature reviews immunology is the highest-ranked journal in the field, with a five-year impact factor of 77.6 and a broad readership spanning basic scientists to clinicians. This review will be of particular interest to immunologists, oncologists, and researchers in cellular therapies and immune modulation.

The article offers a comprehensive overview of how organelles — including mitochondria, lysosomes, endoplasmic reticulum, and peroxisomes — power T-cell metabolism, signaling, and persistence during antitumor responses. Importantly, the authors then discuss emerging therapeutic strategies, including organelle-targeted drugs, the use of organelles as delivery systems for therapeutic cargo, and even the transfer of native or synthetic organelles to boost T-cell efficacy.

By revealing how the inner machinery of T cells can be optimized, this review uncovers an exciting new frontier in therapeutic innovation that could significantly enhance immune-checkpoint blockade and adoptive T-cell therapies.

Dr. Jeremy G. Baldwin, Dr. Christoph Heuser-Loy and Prof. Luca Gattinoni (left to right) are the authors of the article in nature reviews immunology.