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New publication in “Trends in Immunology”: LIT scientist discusses the challenge of T cell subsetting

The article "The T cell subsetting challenge" by Dr. Natalia R. Comet (Karolinska Institutet) and Prof. Carmen Gerlach (Head of Research Division “Tailored T-Cell Diversity” at the LIT), published in “Trends in Immunology”, explores the complexities and inconsistencies in defining and classifying T cell subsets.

Please see full article here!

  • Date Published

    June 24, 2025

 

The publication highlights the lack of uniformity in T cell subset definitions and markers.

T cells can differentiate into various states with distinct functions and properties, yet inconsistencies in nomenclature across studies, complicate data interpretation and hamper clinical translation.

The authors discuss efforts to harmonize definitions through new nomenclature guidelines but emphasize the inherent challenge that markers are only approximations of cell properties.

They argue that understanding these complexities is crucial for advancing T cell-based therapies for cancer and autoimmune diseases.

Prof. Carmen Gerlach

For more information, please visit the full article in the journal “Trends in Immunology”:

Comet N.R., Gerlach C. The T cell subsetting challenge. Trends Immunol. 2025 Jun 16. doi:10.1016/j.it.2025.05.005. PMID: 40527649

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