Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function

Barden M, Elsenbroich PR, Haas V, Ertelt M, Pervan P, Velas L, Gergely B, Szoor A, Harrer DC, Bezler V, Holzinger A, Friis RUW, Vereb G, Schutz GJ, Schoeder CT, Hombach AA, Abken H. Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function. J Immunother Cancer. 2024 Dec 2. 12doi:10.1136/jitc-2024-010208. PMID: 39622582